Actress Katherine Heigl

Atlanta, get set for more Katherine Heigl sightings. Buzz readers will recall that the film and TV actress has already spent a big chunk of time here this year, shooting the upcoming comic thriller “Five Killers” with Ashton Kutcher.

Now that the “Grey’s Anatomy” actress has been granted a five-episode leave from the hit ABC drama,  Buzz can confirm that Heigl is headed back to town this fall to shoot the romantic comedy “Life As We Know It” for Warner Brothers.

The film is set to be directed by Greg Berlanti, a TV producer and series creator best known for his work on “Everwood,” “Eli Stone,” “Dirty Sexy Money” and “Brothers & Sisters.”

Judging from the film’s plot, Berlanti’s expertise in combining comedy with pathos will come in handy. The challenging central story of “Life”: A single guy and girl are thrust together when they’re named guardians of  their best friends’ daughter after the parents die in a car crash.

The male half of the equation?

“Transformers” star Josh Duhamel, who’s already been spotted at the brand-new swanky St. Regis hotel in Buckhead. According to Variety, “Mad Men” actress Christina Hendricks (who plays slinky Sterling Cooper office manager Joan Holloway on the Emmy-addicted AMC series) has also  been signed to co-star in the film.

We’re also hearing that The Mansion in Buckhead could be a locale for star sightings this fall and that scenes for the film could be shot at Turner Field.

The film is slated to shoot into November. Warner Brothers is planning a December 2010 theatrical release.