Best antidepressant for you

Smiling man

Choosing the right antidepressant is tricky. You have many choices and may have heard that they all work the same. After all, the pills are targeting an inadequate amount of a chemical in the brain that transmits signals between neurons. It’s also known as serotonin.

A dozen antidepressants were tested in a new study: Celexa, Cymbalta, Efexor, Ixel, Luvox, Prozac, Seroxat, Remeron, Zyban, Cipralex, Zoloft and Edronax. The winners? Zoloft, developed by Pfizer Inc., and Cipralex, developed by Forest Laboratories in the U.S. and Danish drugmaker H. Lundbeck A/S in Europe, work best.

– By Charles Yoo

Which is your antidepressant? Does it work? How has it changed your life?

91 comments Add your comment


February 3rd, 2009
3:38 pm

Well, I won’t buy it. I have been through a horrible divorce, raised a kid by myself, the loss of more than one job, and the death of a parent. I’m still here, and I’m not depressed. Don’t need medication to make me “right”. I make myself right.

I have been through just about everything posted on this blog, and I’m not depressed.

IT’S A CHOICE!!! And some of you chose to cry “Oh poor me”.

I don’t buy it!


February 3rd, 2009
3:57 pm

Hi, Cindy. Thanks for your responses. I’m trying to better understand your point here. Are you saying that we tend to over-medicate ourselves? Or that depression is not actually a medical condition? What about people whom doctors say are clinically depressed? Should they not be treated with anti-depressants? I’m trying to further our debate. Thanks, everyone.


February 3rd, 2009
4:08 pm

Cyoo – Not Cindy, but one more from shaggy.
I think clinical depression exists is a very small percentage of people, not the millions that drink the cool aid, while needlessly medicating themselves and their children. The doctors and pharm companies set the stage and the media that forces this down the public’s throat are the profiteers in this game. Like my previous post said. It’s the same with ADD ADHD.
Where were all of these millions of “patients” 50 years ago? Why did they mysteriously appear everywhere once a drug(s) was advertised and the BIG story plastered on the news?


February 3rd, 2009
5:37 pm

I can answer the “where were all these millions of patients 50 years ago” question. They were somewhere not getting treatment and causing hell in their homes. My grandmother suffered from anxiety disorder – undiagnosed and untreated – and she was so jittery that she would actually sweat all day just from the anxiety of something happening. She snapped all the time. She was always looking out the window to see if anything was going on. She was depressed a lot. She was mean as a snake sometimes. “Should” she have had any issues with depression or anxiety? Nope…not based on what some of you say. She didn’t work outside the home, unless you count helping my granddaddy clean offices. She didn’t have to go to the grocery store, pump her own gas, take the car for an oil change. She lived farrrrrr from the ‘rat race’ that is supposedly causing people depression. She kept the house, which of course is not easy, but she was her own boss (and my granddaddy’s) and did as she pleased. But still had issues that could have at least been mitigated, in my opinion, with medication and/or talk therapy. I use both and, as I said before, my life is d@mn good because I am stable.


February 3rd, 2009
7:56 pm


I’ll bet if you asked your grandmother if she wanted to feel numb instead of truly feeling emotion, she would have bit you like the snake you describe. That generation delt with their lives differently, with courage and respect. That is something I rarely see today.
Something tells me that you would have forcebly medicated grandma, for her own good, so she would smile and be easier to mansge. What did YOU do to make grandma happy? Did you spend time doing what she wanted to do, or did you remain consumed in your own unhappiness, watching her and giving up hope for your own happiness because of her? It’s just a cop out to blame unhappiness on others, even direct family. Your life starts and ends with you.


February 3rd, 2009
8:01 pm

Shaggy and Cindy, if you don’t believe depression exists, why are you getting involved in a forum about treatments for it? I don’t see what purpose it serves to try to antagonize people who are at the very least acknowledging that they are struggling.


February 3rd, 2009
8:19 pm


Learn to read posts. It is healthy to understand a point before you attempt to make your own. Why do you think it is antagonization to disagree?
Let me break it down for you:
Too much heavy, addictive, personality altering drugs prescribed by an industry that makes a lot of money on these drugs that suddenly appeared for a much ballyhooed condition shoved down the public’s gullible throat by a profiteering, advertising media.
Signed, “those of us that find beauty everywhere and nowhere at the same time.”


February 3rd, 2009
10:32 pm

Minimizing someone else’s illness by calling them a “whiner” and suggesting they kill themselves is antagonizing. And not very constructive behavior for someone who claims to see beauty everywhere.


February 4th, 2009
7:07 am


Sorry for the check out thing. However, I firmly believe that unless someone or something has control over your life, liberty, pursuit of happiness, you are in control of your happiness. Living addicted to dubiously approved, costly, and personality changing drugs does not, in my opinion, equate happiness, and yes, I would rather not exist than live like that.

I once loved a woman, a very beautiful, energetic, engaging woman, who went through some life challenges. She thought she needed to see a doctor, because her peers convinced her that she needed help.(not me. I thought she was fine, just going through some tough times) The doctor promptly put her on prozac, one visit, here’s your script. The change in her otherwise vibrant personality was profound and chilling. She was a different person, one who smiled on the outside and was numb on the inside. It was like a high spirited horse that had suddenly been beaten into submission. Yes you could ride it, but it really was only a shadow of its former self. Thankfully, she allowed me to persuade her to see a different doctor (mine), with me there. (it will help this story for you to know that she is my wife) This is an older doctor, who can tell you stories of delivering babies in peoples homes. Old School. Once he found out the whole story, including the hurry up prozac prescription, he first recommended she wean herself off of it. During that time period, his recommendation was to identify things SHE really wanted to do in her life and make achievable plans to do them. It took 9 months for her to get off of that crap, however she ended up clean and is today, doing the things that make HER happy. That energetic, beautiful, intelligent woman was returned to me by her own hand.
So, please excuse my opinionated writing. I have seen this and yes, I was forced to further research it and take action, because I wanted my wife back, not the medicated woman that woke up beside me.


February 4th, 2009
7:35 am

Shaggy very well written. And congrats!!!


February 4th, 2009
11:07 am

Why are people on this blog. that don’t have depression or believe in taking medicine for mental illness.. yet spewing judgment and negative energy about those that seek treatment. Are you lonely, full of pent up rage, and tired of not being heard? Perhaps, you have a mental illness but are too ignorant to get help for it.


February 4th, 2009
12:58 pm


How can you type when your hands are shaking uncontrollably and spittle is getting on the keyboard from gritting your teeth while hissing?

married to it

February 4th, 2009
1:21 pm

Yes, there are some people on anti-depressants who don’t really need it just like any other medication. But this should not minimize the people who truly have a chemical imbalance and do require meds to give them a better life. My husband recently went back on meds after being on and off for the last 10 years or so. He did not want to go back on them but got to the point where everyday he would try to convince himself to be happy, focusing on his family, his job, how fortunate he was in every way, but still the depression sank in. He exercises every day, is fit, has a hobby that he finds great emotional release in yet, nothing helped like the meds. He did have issues with a doctor prescribing a dosage that was too high, causing that numb feeling, and was lucky enough to find another doctor who cut the dose in half. He still feels sadness and anger, but these no longer dominate his each and every day.

married to it

February 4th, 2009
1:29 pm

oh, and he hated paxil. zoloft has worked much better with minimal side effects.


February 4th, 2009
1:41 pm

The key thing is regular sex and not just because of the chemicals that’re produced.No one seems to have brought that subject up. It’s right after Air, water, food and shelter. Back down that Maslow ladder until you’re skipping something. 9 times out of 10 there’s no sex in your life. If I don’t get it I’m depressed as all get out–with it I can tackle anything.

Asha Mulchan

February 4th, 2009
8:46 pm

I do a daily program of breathing techniques which I learnt in the Art of Living stress management/health promotion program almost 11 years ago – it is my daily medicine, it has no unwanted side-effects, but many fringe benefits. I have very low stress levels, an improved immune system, peace of mind and a general positive and uplifting attitude. My children and I (yes, they do the breathing, too!) very seldom get sick. Research of the program has shown reduced levels of stress; improved immune system; reduced cholesterol; decreased anxiety and depression (mild, moderate and severe); increase in anti-oxidant protection; increase in natural killer cells, and enhanced well-being and peace of mind. I’ve gone through many traumatic events (e.g., a horrible divorce, a difficult move back to the US from Europe, the murder of my daughter’s fiancé and her intense suffering, losing two jobs due to budget cuts and downsizing). I moved through all of these without therapy and without meds and that is a real miracle to me.


February 8th, 2009
4:12 pm



February 8th, 2009
4:16 pm



February 8th, 2009
8:09 pm


I don’t want to upset you or scare you into a panic, but step away from the caps lock key on your computer. After you stop cyber yelling, you might get some feedback.

Why do people do this anyway? When any post is in caps lock, I usually read about one line and give it up.


February 18th, 2009
6:21 am

I can completely understand why Cindy & Shaggy are expressing their concerns w.r.t. using medication to treat depression in this forum, as I was once felling exactly the same way they do…that was until I was diagnosed with generalised anxiety disorder – commonly treated with the same anti depressant medications to control neurotransmitter chemicals in the brain…

All I can say is… No, one cannot “think” youselve out of depression or anxiety. Attitude is important, but only if one acts responsibly and use these medications in cases where “mind over matter” won’t “fix things”…

I’ve been on Cipralex for almost 5 months now, and for the first time feel “normal” – the way I used to before my chemicals have gone “haywire”…

Too all those using these medications, well done & good luck with finding the right one.

People always look for “miracles” that would instantly cure their conditions, but never stop to think that these medications are our modern “miracle”, inspired by the knowledge that God has instilled in each and every one of us. Why not use what HE’s been giving us and stop seeing it as the DEVIL…

Only my humble opinion, but I thank GOD everyday for the lessons I’ve learned through this experience. Not judging people who are suffering with depression and/or anxiety. Unless you are in their shoes, do not give advise…


March 3rd, 2009
9:13 pm

As someone who has tried ALL the natural remedies from exercise to positive thinking to fish oil to St. John’s Wort, to meditation, I can tell you that nothing has pulled me out of major depression like Paxil. I took it for 20 months with few side affects. Went off because of weight gain and despite my best efforts fell into another major depression. Paxil didn’t work the second time and now I am in process of finding something else.
I was devastated when I realized that my strong spiritual life and healthy living wouldn’t cure my depression. Then I realized that that is as silly as expecting prayer and exercise to “cure” my husband’s Type I diabetes. Prayer and exercise are extremely important in helping him stay healthy, but they are no substitute for his insulin. Major depression isn’t “feeling sorry for yourself” or being a little blue. It is a very real, very physical illness. Be grateful every day if you have never experienced it.


March 3rd, 2009
9:21 pm

Oh, let me add, obviously I’m a different Cindy from the one who doesn’t believe in depression as an illness. Just because you go through terrible things in life and don’t get depressed doesn’t mean it doesn’t exist for others. Some people smoke all their long lives and don’t get lung cancer. Does that mean smoking doesn’t cause cancer? Some people are blessed with more serotonin than others. If you are be grateful.


March 17th, 2009
2:57 pm

Shaggy and cindy are morons….don’t know how they wandered to this page, and wonder why they don’t have anything better to do than talk smack to depressed people….i have been on paxil for 5 years, excercise every day, and take time to breath…works for me


March 20th, 2009
2:29 pm

Anyone on here who denies the existence of depression, has obviously NOT suffered from it. I have been on anti-depressants since the end of 1999, because these things happened to me: I was diagnosed with Crohn’s Disease and underwent emergency surgery during which I nearly died. I was in hospital for 8 weeks. The following year I had further surgery. I have an ileostomy bag for the rest of my life (I’m now 36). I’ve had endless financial problems, my mother died in 2002 and now I’m a full-time carer for my father who has vascular dementia. Depression is an ILLNESS which is caused by problems with neurotransmitters in the brain. Research has shown that people who inherit a certain version of the serotonin transporter gene are susceptible to depression, obsessive compulsive disorder and autism spectrum disorders. Serotinin, dopamine, noradrenaline etc are chemicals in the brain and the body, just as insulin is a chemical.Some of the posters on here really need to think about the rubbish they are coming out with, or they need to experience the same feelings that I’ve experienced: feeling suicidal, not being able to think, not being able to concentrate, feeling overwhelmed with fear which you think you’ll never get over…..paradoxically, a feeling that you really are about to die yet you don’t want to, or that you are falling further and further down a dark pit which you can’t get out of. To anyone who stills refuses to believe in depression: try living my life and THEN see how you feel.


June 16th, 2009
8:41 am

All of you offering platitudes and criticism of those who have suffered from something about which you know nothing need to get on your knees now and pray you never suffer from major depression.


July 11th, 2009
11:06 pm

having issues right now, have a family history of depression, many drugs have not worked for me, i took paxil for about six years, it helped tremendously, but i didnt like the effects i would have if i missed a dose (dizziness, lightheadedness) plus it was horrible to get off of. havent taken anything in two years but having the same issues again, dr, just put me on celexa. is celexa the same as lexapro? because my dad has been taking lexapro and it hasnt worked for him. i felt almost immediate relief from the paxil, i started taking the celexa a few days ago and am feeling very lightheaded and miserable.


July 14th, 2009
1:04 pm

Cindy and Shaggy are just uneducated about the issue just like Scientologist Tom Cruise who believes aliens populate earth. Chemical imbalances exist and are real regardless of what ignorant people believe. Luckily I’ve had the ability to recognize this and have sought help as a result. I’ve had a chemical imbalance since I was a teenager and have had depression / anger episodes which resulted in the hospitalization of other people that I beat to a pulp because I have neglected to take medication. Back then I didn’t care because I was chemically imbalanced. Nowadays, I would much rather be even-keeled than run the risk of hurting someone. Furthermore, I’m doing things that make me happy, counterpoint to these people who think doing things that make you happy are the cure-all, they’re not. Moreover, I credit my position in life as an executive in a fortune 500 company to taking this medication. Some people need help and to back up the other Cindy’s point, be glad you are blessed with healthy seratonin levels and leave the people that are in true need to find the answers they seek.


July 22nd, 2009
9:38 am

Sorry to say this, Pot is not the answer, but it is alot of fun. it has a lot of negitive affects to the human body as well. My depression is often amplified while smoking pot which throws my body into a lifeless state now i have just taken the first half of cipralex no more the 22 min ago so i will come back here in a mnth and give you guys the real answer on that medication.


July 22nd, 2009
2:18 pm

Hi there – would just like to add my little bit …

ok, so for about 3 years had been on cipralex for a combination of post-natal depression and the fact that I found out that my husband was having an affair. The drug itself was amazing and the only side-effect that I had was about 28lbs of weight gain which is a bit of a bummer for someone that has always been able to eat whatever she wants……anyway, I read about Wellbutrin on the internet (marketed as Zyban in the UK) and read that it caused weight loss, was an ani-depressant and also stopped you from smoking. Perfect.

I went to my doctor who prescribed me Zyban (to do all 3 things in one!!) and we also talked about weaning me off cipralex in the process. I had been keeping a diary and had no problms at all until around day 30 when I had not taken cipralex for around 7 days. Previous to that I had been taking 150mg Zyban every day and 5mg of cipralex every 3 days. Now I have had around 9 days with no cipralex at all and i feel awful. I am snappy, I have a strange buzzing feeling in my ears and brain and I can’t stop crying. I am also blushing when talking to people and I just don’t feel like “me”. The problem is that I don’t know if it’s the side effects of not having cipralex for so long or the side effects of having zyban.

I have just taken 5mg of cipralex and am going to see how I feel tomorrow. THis is so horrible at the moment though. Ifeel as though I am in a cloud and am very detached. Would love to hear if anyone else has ever felt like this X


August 8th, 2009
10:09 pm

I have been on cipralex for about 3 months now. I noticed within the first couple of days I felt different and the drug has worked wonders for me and has made me more positive and stress free.
I have never been on anti-depressants before and never believed in them until I felt I was just fed up with the struggle.
I have managed to lose 10 llbs or more give or take because my hunger has decreased but other than that I havent experienced much side affecrs but am starting to become concerned.
I recently was in a crowd of ppl waiting in a line and experience dizziness, blindness and almost a panic atttack. Ive never had one so Im not sure. It was almost as if my blood sugar was really low or something and I could of fainted. I got my bf to take me outta there and felt better but is this because of the meds?
I also smoke a lot of pot and always have. Im wondering if Im doing more damage, and it’s obvious that pot isn’t the best thing for u but I love smoking it. Is it time to quit or is it that I need to eventually get off the cipralex? I don’t want to be dependant on this forever but i was always really sad or depressed before.


August 14th, 2009
6:00 pm


Depression runs in my family. I have a strong mental stand & believe in mind over matter. Will power is everything.. unless you have true deep depression. Let me say a few things before getting my final point across.

Everyone deals w/ feelings/emotions/thoughts & physical reactions differently. I’ve had extreme anxiety since I was a kid. It manifested into different things as I was growing up. Finally, ending in panic attacks. I then learned to “control it” mentally. I feel relieved that I understand more about the disease as well as myself. However there is another “friend” I have to live with: Depression. I’ve tried to make it “go away”. All kinds of excersize, getting enough sun, being around positive people, experiencing a new awaking to my Lord & Savior Christ Jesus. Yes, so much I have done to manage it “Naturally”. But guess what?! All you who don’t have depression just do not have room to judge, or give advice. It’s something you are born with & I believe certain situations/circumstances trigger it* It varies in degress of how bad or how managable it can be. However, I believe once you have it you can’t get rid of it. Maybe for a few days, months or years. But overall, it comes back. That is when you have to accept it, learn from it & grow stronger & wiser to your own body, mind, soul & hopefully spirit. Realize you can’t grow alone.

Get help if you need it.

That’s what I finally have done. To sum it all up I am ‘dreadfully’ looking forward to trying a mood inhancer/antidepressant for the first time* wish me good decision making & I will keep you updated. Research has left me more confused than ever & Blogs aren’t much help. -mine probably wasn’t either* But for this moment I feel just that much better.



September 1st, 2009
12:16 pm

Paxil (paroxetine) has had a very bad press over the years but can be highly effective for certain individuals. I’ve witnessed patients’ lives literally being turned around in a matter of weeks. Is it the panacea to all their ills? No of course not. But it’s a start in the right direction and can enable very ill people to gradually get their life back. I’m not specifically promoting Paxil as there are numerous antidepressants available and it’s not possible to determine in advance how a particular drug will affect a particular individual.

As for those who talk about exercise, the power of prayer etc. please go and educate yourselves. Try reading the relevant sections of DSM-IV or ICD10 and then maybe you might have something worthwhile to contribute…


September 17th, 2009
2:10 pm

i have extreme anxiety and Depression runs in my family and there has been a lot of things that have made me what iam today i can not eat solid food most of the time my chest becomes tight and i start to think am going to choke if i eat this i have to push myslfe day after day just to eat and not give up because i dont want to give in to the everyday pain that anxiety and depression give you i tryed so hard to go on without the drugs iam only 21 years old but it got to the point where it was just to much to deal with i would cry everday to the point where my body was tired from crying i could not work at a job i once loved any more life use to not be so bad people that live a every day happy life and not to have the feelings of what people with anxiety and depression have then just be thankful of your everday joy and do not put down people like us with it it hurts i just want my life back i want it more then anything not to be able to love food like i use to sucks so every time you pick up something you just love to eat like pizza just love every bit of it and just be lucky you dont have what i have i would love to eat pizza i try hard to eat it but the fear comes over me and it hurts a lot that i cant do it like everyone els all i can say i hope to hell cipralex works for me and good luck to all to a happy life


September 29th, 2009
7:49 pm

for all the people saying depression is somebody’s fault and something that can be treated with vitamins/exercise etc- i would dare you to say that to a rape survivor such as myself. at 21 years of age i am the editor in chief of a magazine, 3.6 gpa, published journalist and i have been through many episodes previously in my life such as the divorce of my parents and deaths of friends and family which i was able to cope with and deal with. sometimes it is NOT a matter of exercising and rewiring your thinking. in my situation i was TOLD by a therapist that i was suffering from depression- i didn’t even realize how much my life was affected my sexual assault. so before you start spouting off about how people on antidepressants just need to learn to cope, i suggest you put yourself in my shoes and the 1/4 of women who are raped and ask them to get over their depression alone or just ‘deal’ with it.


October 1st, 2009
8:59 am

I’m reading some of these posts, and you can CLEARLY tell the ones who are on here bashing anti-depressants, haven’t the slightest clue what they are talking about. You people have no business talking about something you know nothing about. I have a wonderful life, I am a youth leader at my church, have the best family in the world, a good job, nothing to be “depressed” about. But I was DIAGNOSED with manic depression at a very young age, and will always have to take them. They are not addictive, and when I stop taking them, everyone can tell a HUGE difference….myseld included. No one “chooses” depression….it is a serious medical condition. So yes, pray, exercise, whatever helps….but without anti-depressants NOTHING will help when you are depressed. I take Pristiq now and it is by far the best one i’ve taken, and i’ve taken them all. No side effects…just simply the best anti-depressant i’ve ever taken and I highly recommend it to anyone suffering from mild to manic depression.


December 27th, 2009
2:14 am

I’ve been off and on using Cipralex for the last three years. Anxiety, with the odd panic tack and then a long lasting depression were my symptoms – I suppose like many of you. During the summer I found that 10mg seemed to be sufficient to maintain a balance that would allow me to maintain some sense of normality – In the winter months and increase to 20mg was necessary as I wasn’t out exercising as much (which is absolutely key for the depression). The toughest side effect seems to be drowsiness and feeling out of energy at points during the day. Again, any cardio-exercise that can be done inside or out has had a tremendous impact on my energy levels. Libido, does get effected, but fortunately I can still get to where I need to with a little patience. Other, than that, I haven’t had to contend with any other serious issues – My family is at ease and I can actually look forward to each day, rather than dreading every waking moment. I highly recommend Cipralex for anyone suffering similar difficulties who may go through serious complications with other medications. Patience is key as it actually takes about 3 weeks to a month before the positive effect start to kick in. For me it’s been a life saver…

Louise Towers

February 1st, 2010
7:19 pm

First of all, Cindy, What part of Chemical Imbalance do you not get? Yes, exercise outside is great if you can do it. Fresh air is wonderful and does help you feel better if you have the blues..NOT Clinical Depression. For those of you who know what Clinical Depression is, I have a question.

Recently I tried Cipralex. Almost immediately I could feel the weight of the world rising. I couldn’t cry any more (an ok thing as I was waking up crying) but I viewed the world entirely differently and was happy. I got… not a normal symptom…but a very rare one…. muscle rigidity. My shoulders would suddenly be up around my I would try to relax then, then find that my head was being held an inch or so up from the pillow, or my feet were turned up ot my leg pulled up into my hip socket. NOT a muscle spasm but a constant tenseness which is exhausting. I told the doctor and she had me drop my dosage for a week and then last week she switched me over to Zoloft which does not make me as happy, but unfortunately there has been no change in the rigidity. I am seeing my Dr on Thursday and am afraid she will probably wean me off the Zoloft and see if I still have the problem.

Have any of you ever had this muscle tenseness? I am achy and so tired from holding my muscles like that all the time.

I know that Cipralex and Zoloft are from the same family of SSRI’s and that there are many other types of antidepressants to try. most of them are not covered by my medical plan.


April 19th, 2010
3:23 am

why is all this from feb 09 it is april 2010. wondering if anyone out there uses effexor and cipralex or some other combo that works, i used prozac and it worked well but i stopped it due to side affects and now effexor takes the edge off but i need something else, i hike swim walk work listen to music socialize but still need something else what???

on things itself

May 17th, 2010
5:59 am

Only fools and horses work, the writing style is creative.


July 2nd, 2010
12:37 pm

I just want everyone to be very careful when taking cipralex, with other medication.
I was given cipralex for anxiety and torodol for pain after a car accident.
I suffered from extreme mucles shaking and twitching, convulsions,and sezures.
I became incoherant, and hallucinated.
I sought help from my doctor, two trips to the Emerg, and a neurologist.
No one could figure out what was wrong with me.
I knew in my gut that something was terribly wrong, and I was losing total control over my body and mind.
Once they ruled out all the big stuff, they thought well it’s got to be in her head.
I knew I couldn’t possibly be doing this to myself, and a shrink agreed!
Then when I was close to giving up hope my doctor said when don’t you try going off the medication, we’ve tried everything else.
Wow 12 months of hell, and no one thought,”hey it could be her medication”.
With in a few days I noticed a huge difference.
Within a month I felt fantastic.
So I lost a year of my life, but I learned a very big lesson.
Only you know your body best.
Listen to your gut, and keep hounding the doctor’s until you are better.
If this can help just one person, it will justify what I had to go through.


July 30th, 2010
8:09 pm

I have used Zoloft on and off since 1995 and I have been very pleased with the results. I really didn’t experience a significant weight gain until I took 100 mg. Then it was only about a 15 pd increase in body weight. It is worth mentioning that I have taken this medicine consistenly for over 5 years. My maintance dose seems to be aprox. 50 mg. This medicine has helped me overcome an eating disorder, social anxieties, and depression. I considered changing medicines just to see what else is out there and based on the research I found, zoloft is one of the best anti-depres. on the market. I did read that Lexapro is an excellent choice as well. Good luck to anyone considering a medication- I hope my review helps.